Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis

作者:Magalhaes Ana; Duarte Henrique O; Reis Celso A*
来源:Cancer Cell, 2017, 31(6): 733-735.
DOI:10.1016/j.ccell.2017.05.012

摘要

Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.

  • 出版日期2017-6-12