Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium

作者：Liu, Xue-Ting; Schwan, William R.; Volk, Thomas J.; Rott, Marc; Liu, Miaomiao; Huang, Pei; Liu, Zhong; Wang, Ying; Zitomer, Nicholas C.; Sleger, Cassandra; Hartsel, Scott; Monte, Aaron; Zhang, Lixin^*

来源：Journal of Natural Products, 2012, 75(9): 1534-1538.

DOI：10.1021/np300221a

• BIOLOGICALLY-ACTIVE METABOLITES
• ENDOPHYTIC FUNGUS
• CLADOSPIRONE BISEPOXIDE
• ABSOLUTE-CONFIGURATION
• ANTIFUNGAL METABOLITES
• SECONDARY METABOLITES
• STRUCTURE ELUCIDATION
• PREUSSOMERINS
• INHIBITORS
• STEREOCHEMISTRY

Urnucratins A-C (1-3), which possess an unusual bisnaphthospiroether skeleton with one oxygen bridge and one C-C bridge and represent a new subclass of bisnaphthalenes, were isolated from the North American cup fungus Urnula craterium. Their structures, including absolute configurations, were determined by means of FIRMS, NMR, and quantum chemical CD calculations. Urnucratin A (1) was found to be active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and Streptococcus pyogenes with MIC values of 2, 1, and 0.5 mu g/mL, respectively.

• 出版日期2012-9
• 单位暨南大学; 中国科学院微生物研究所