A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay

作者:Chamakuri Srinivas; Guduru Shiva Krishna Reddy; Pamu Sreedhar; Chandrasekar Gayathri; Kitambi Satish Srinivas*; Arya Prabhat
来源:European Journal of Organic Chemistry, 2013, 2013(19): 3959-3964.
DOI:10.1002/ejoc.201300409

摘要

A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent stitching technology. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.

  • 出版日期2013-7