Histological insights into the pathogenesis of post-Roux-en-Y hyperinsulinaemic hypoglycaemia

作者：Lash R W; Giordano T J; Moraitis A G; Hodish I^*

来源：Diabetic Medicine, 2014, 31(12): E29-E32.

DOI：10.1111/dme.12571

Background beta-cell hyperplasia has been implicated in the aetiology of post Roux-en-Y gastric bypass hyperinsulinaemic hypoglycaemia, but the pathogenesis of this condition is still unclear.
Case report We report a case of a 52-year-old man with post-Roux-en-Y gastric bypass hyperinsulinaemic hypoglycaemia who underwent distal pancreatectomy to alleviate his symptoms. Pancreatic histopathology showed chronic pancreatitis with a corresponding loss of exocrine tissue and islet retention. Amyloid deposition was found in pancreatic islets. These features are more typically associated with Type 2 diabetes.
Discussion This case highlights the potential multifactorial pathogenesis of symptomatic hypoglycaemia after Roux-en-Y gastric bypass.

• 出版日期2014-12