A Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice

作者:Reiter Russel J*; Tan Dun Xian; Manchester Lucien C; Korkmaz Ahmet; Fuentes Broto Lorena; Hardman W Elaine; Rosales Corral Sergio A; Qi Wenbo
来源:Cancer Investigation, 2013, 31(6): 365-373.
DOI:10.3109/07357907.2013.800095

摘要

It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.

  • 出版日期2013-7