A fast track strategy toward highly functionalized dendrimers with different structural layers: an "onion peel approach"

作者：Sharma Rishi; Zhang Issan; Abbassi Leila; Rej Rabindra; Maysinger Dusica^*; Roy Rene

来源：Polymer Chemistry, 2015, 6(9): 1436-1444.

DOI：10.1039/c4py01761g

An accelerated strategy depending on different chemical building blocks between each layer, coined "onion peel", was used to construct a library of third generation dendrimers with 108, 180 and 252 hydroxyl surface groups using a combination of microwave assisted highly efficient CuAAC and thiol-ene reactions. These dendrimers were conveniently acquired with high purity and good yields in a divergent manner using a variety of orthogonal and dense AB(3), AB(5), and AB(7) building blocks. The resulting poly-hydroxylated dendrimers tested in several human cell types did not impair mitochondrial metabolic function or cell viability suggesting that they are good candidates for applications in biological investigations.

• 出版日期2015
• 单位McGill