The Use of Conjunctival Pedicle Flaps to Prevent Corneal Perforation in Graft-Versus-Host Disease

作者：Kim Min Ho; Chung So Hyang; Kim Hyun Seung; Na Kyung Sun^*

来源：Seminars in Ophthalmology, 2017, 32(4): 462-465.

DOI：10.3109/08820538.2015.1119860

• Barrier
• conjunctiva
• corneal perforation
• graft-versus-host disease
• pedicle flap

Purpose: We report the clinical outcomes of two chronic graft-versus-host disease (cGVHD) corneal thinning cases that were successfully treated with conjunctival pedicle flaps in an effort to prevent impending corneal perforation. Methods: The patients were treated with topical and systemic corticosteroids, therapeutic contact lenses, lubricants, and punctual plugs. Conjunctival pedicle flaps were used because conventional treatments had failed, and corneal perforation was imminent. Results: Both patients were successfully treated with conjunctival pedicle flaps. Following conjunctival flap removal, one patient had corneal clarity restored following penetrating keratoplasty. Conclusions: Conjunctival pedicle flaps provided a strong barrier for the corneal surface and stabilized anterior chamber in cGVHD patients with impending corneal perforation following allogeneic hematopoietic stem cell transplant.

• 出版日期2017