A facile strategy for the one pot multicomponent synthesis of spiro dihydropyridines from amines and activated alkynes

作者：Kiruthika Selvarangam E; Lakshmi Neelakandan Vidhya; Banu Babu Rasidha; Perumal Paramasivan T^*

来源：Tetrahedron Letters, 2011, 52(48): 6508-6511.

DOI：10.1016/j.tetlet.2011.09.119

• Multi-component reactions
• Spiro dihydropyridines
• Monoketones
• Diketones
• Activated alkynes

An efficient preparation of a series of Spiro dihydropyridines via one pot four-component reactions of mono/di/tri-ketones, malononitrile, primary amines, and acetylenic esters is reported. The reaction is atom-efficient, high yielding, and follows a simple experimental procedure.

• 出版日期2011-11-30