A Prospective Trial Showing the Safety of Adjusted-Dose Enoxaparin for Thromboprophylaxis of Pregnant Women With Mechanical Prosthetic Heart Valves

作者：Saeed Chitsike Rufaro^*; Frank Jacobson Barry; Pravin Manga; Aziz Rhemtula Haroun; Serasheini Moodley; Dominique Toweel Gabrielle

来源：Clinical and Applied Thrombosis/Hemostasis, 2011, 17(4): 313-319.

DOI：10.1177/1076029610371470

• mechanical prosthetic heart valves
• pregnancy
• enoxaparin

Objective: To determine whether dosage adjustment of enoxaparin during pregnancy, to maintain a peak anti-Xa of 1.0 to 1.2 U/mL, is safe for women with mechanical prosthetic heart valves (MPHV). Design: A prospective observational study. Setting: This study was performed at Charlotte Maxeke Johannesburg Academic Hospital from 2007 to 2009. Population: Fifteen women with MPHVs. Methods: Women were treated with enoxaparin with dosage adjustment to achieve a peak anti-Xa of 1.0 to 1.2 U/mL. Main Outcome Measures: Main outcomes measured were prosthetic valve thrombosis, bleeding, and maternal mortality. Results: There was no maternal mortality. None of the women developed valvular thrombosis during pregnancy. In all, 2 women developed epistaxis and another developed spotting per vaginum. Conclusion: Our data show that enoxaparin may be administered safely during pregnancy to pregnant women with MPHV when there is dosage adjustment throughout pregnancy to maintain an anti-Xa of 1.0 to 1.2 U/mL.

• 出版日期2011-8