A Caenorhabditis elegans Insulin-Like Peptide, INS-17: Its Physiological Function and Expression Pattern

作者：Matsunaga Yohei; Nakajima Kensuke; Gengyo Ando Keiko; Mitani Shohei; Iwasaki Takashi; Kawano Tsuyoshi^*

来源：Bioscience Biotechnology and Biochemistry, 2012, 76(11): 2168-2172.

DOI：10.1271/bbb.120540

• antagonist
• Caenorhabditis elegans
• insulin-like peptide
• larval diapause
• spatio-temporal expression

The insulin/insulin-like growth factor-1 signaling pathway of Caenorhabditis elegans regulates larval diapause and adult lifespan through the sole insulin receptor-like protein, DAF-2. In the present study, the physiological function and expression pattern of INS-17, one of the C. elegans insulin-like peptides, were examined by disruption and overexpression of the gene, and by the use of a reporter gene. INS-17 might function as a DAF-2 antagonist in the regulation of larval diapause, but not of the adult lifespan. The reporter protein was intensively expressed during larval diapause. It showed a drastic decrease in amount after larval diapause, which matches well the physiological function of INS-17.

• 出版日期2012-11