A case of hypophosphatemic osteomalacia secondary to deferasirox therapy

作者：Milat Frances; Wong Phillip^*; Fuller Peter J; Johnstone Lillian; Kerr Peter G; Doery James C G; Strauss Boyd J; Bowden Donald K

来源：Journal of Bone and Mineral Research, 2012, 27(1): 219-222.

DOI：10.1002/jbmr.522

• DEFERASIROX
• IRON-CHELATION THERAPY
• ss-THALASSEMIA MAJOR

Patients with beta-thalassemia major require iron-chelation therapy to avoid the complication of iron overload. Until recently, deferoxamine (DFO) was the major iron chelator used in patients requiring chronic hypertransfusion therapy, but DFO required continuous subcutaneous therapy. The availability of deferasirox (Exjade (R)), an orally active iron chelator, over the past 4 years represented a necessary alternative for patients requiring chelation therapy. However, there have been increasing reports of proximal renal tubular dysfunction and Fanconi Syndrome associated with deferasirox in the literature. We report a case of hypophosphataemic osteomalacia secondary to deferasirox therapy.

• 出版日期2012-1