A New Diarylheptanoid Glycoside from the Stem Bark of Alnus hirsuta and Protective Effects of Diarylheptanoid Derivatives in Human HepG2 Cells

作者：Park Daae; Kim Hyoung Ja; Jung Seo Yun; Yook Chang Soo; Jin Changbae; Lee Yong Sup^*

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58(2): 238-241.

DOI：10.1248/cpb.58.238

• Alnus hirsuta
• diarylheptanoid derivative
• hepatoprotective effect
• tert-butylhydroperoxide
• HepG2 cell

To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations of the ethyl acetate soluble fraction of the stem bark of A. hirsuta led to the isolation of a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-beta-D-glucopyranosyl(1 -> 3)-beta-D-Xylopyranoside (13) and twelve diarylheptanoid derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-beta-D-glucopyranoside (3), rubranoside B (4), rubranoside C (5), hirsutanonol (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9), platyphyllonol 5-O-beta-D-xylopyranoside (10), aceroside VII (11) and platypyllenone (12). Isolates were assessed for their hepatoprotective effects against tert-butylhydroperoxide (t-BHP)-induced toxicity in HepG2 cells. Of these isolates, compounds 1-8 showed significant hepato protective effects on t-BHP-induced damage to HepG2 cells, with 8 exhibiting the greatest protective effect (50.7 +/- 3.7% at a concentration of 10 mu m).

• 出版日期2010-2