A triple-functionalised metal centre-catalyzed enantioselective multicomponent reaction

作者：Wei, Qinghua; Ma, Xiaochu; Chen, Jianghui; Niu, Li; Yang, Xi; Xia, Fei; Liu, Shunying^*

来源：Organic Chemistry Frontiers, 2018, 5(19): 2799-2804.

DOI：10.1039/c8qo00703a

• C-C BOND
• ASYMMETRIC ARYLATION
• RH(I)-CATALYZED REACTION
• CYCLOADDITION REACTIONS
• 3-COMPONENT REACTION
• CARBENE INSERTION
• AMMONIUM YLIDES
• DIAZO-COMPOUNDS
• H BONDS
• ALKENES

An enantioselective multi-component reaction (MCR) was exquisitely developed by using a catalytic model of a triple-functionalised metal centre in a Rh-I/(DHQ)(2)PHAL system via multiple coordination interactions. The catalytic reactivity of the Rh-I centres was critically modulated by a complex dissociation process rather than a common ligand exchange process. The developed MCR offers a mild, atom-efficient, and step-economical method to construct 3,3-disubstituted oxindoles with high diastereo- and enantioselectivities. This study provides an efficient example that gives insight into a strategy for the discovery of MCRs by using high-coordination-number transition metals as multiple functional catalytic centres.

• 出版日期2018-10-7
• 单位华东师范大学