Dihydrofolate reductase inhibitory peptides screened from a structured designed beta-loop peptide library displayed on phage

作者：Tsutsumi Hiroshi; Nakano Kazuhiko; Mihara Hisakazu^*

来源：Molecular Biosystems, 2015, 11(10): 2713-2716.

DOI：10.1039/c5mb00316d

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel beta-sheet scaffold (beta-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained beta-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.

• 出版日期2015