A spontaneous Type 1 electrocardiogram pattern in lead V-2 is an independent predictor of ventricular fibrillation in Brugada syndrome

作者：Nakano Yukiko^*; Shimizu Wataru; Ogi Hiroshi; Suenari Kazuyoshi; Oda Noboru; Makita Yuko; Kajihara Kenta; Hirai Yukoh; Sairaku Akinori; Tokuyama Takehito; Tonouchi Yukiji; Ueda Shigeyuki; Sueda Taijiro; Chayama Kazuaki; Kihara Yasuki

来源：Europace, 2010, 12(3): 410-416.

DOI：10.1093/europace/eup446

• Brugada syndrome
• Risk stratification
• Ventricular fibrillation
• Atrial fibrillation
• SCN5A
• Sudden death

Aim Risk stratification for Brugada syndrome remains controversial. We investigated the relationships between episodes of ventricular fibrillation (VF) and various clinical, electrocardiographic, electrophysiologic, and genetic parameters both retrospectively and prospectively.
Methods and results Fifty-two patients with Brugada syndrome (49 men, average age 42 +/- 3 years) were studied. In the Brugada patients with a VF history, the frequency of a spontaneous Type 1 electrocardiogram (ECG) pattern in lead V-2 was significantly higher and the STJ amplitude in the V-1 and V-2 leads was also higher than in those without a VF history. Multivariate analyses revealed that the spontaneous Type 1 ECG pattern in lead V-2 (but not lead V-1) was the only independent predictor of a VF history. During a mean follow-up period of 39 +/- 4 months, 38.8% of the patients with a VF history and 2.9% of those without experienced an appropriate implantable cardioverter-defibrillation owing to VF. A multivariate analysis using a Cox's proportional hazard model showed that a VF history and spontaneous Type 1 ECG pattern in lead V-2 were independent predictors of subsequent VF events.
Conclusion A spontaneous Type 1 Brugada ECG pattern in lead V-2 (but not lead V-1) was both a prospective and retrospective independent predictor of VF episodes in Brugada syndrome.

• 出版日期2010-3