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摘要
The direct vinylogous aldol reaction of alpha-substituted alpha,beta-unsaturated aldehydes with isatins is described. The chemistry provides easy access to valuable 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol and perfect gamma-site selectivity. Preliminary mechanistic studies suggest that, depending on the nature of the a-branched enal substituents, two divergent reaction mechanisms can be operating, leading to different products and stereochemical outcomes.
- 出版日期2012-11-2
