Differential performance of first-trimester screening in predicting small-for-gestational-age neonate or fetal growth restriction

作者：Crovetto F; Triunfo S; Crispi F; Rodriguez Sureda V; Dominguez C; Figueras F^*; Gratacos E

来源：Ultrasound in Obstetrics and Gynecology, 2017, 49(3): 349-356.

DOI：10.1002/uog.15919

• fetal growth restriction
• first-trimester screening
• placental growth factor
• small-for-gestational age
• soluble fms-like tyrosine kinase-1

ObjectiveTo assess the ability of integrated first-trimester screening, combining maternal characteristics and biophysical and biochemical markers, to predict delivery of a small-for-gestational-age (SGA) neonate, and compare this with its ability to predict fetal growth restriction (FGR).
MethodsThis was a prospective cohort study of singleton pregnancies undergoing routine first-trimester screening. SGA was defined as birth weight (BW) < 10(th) percentile and FGR was defined as an ultrasound estimated fetal weight < 10(th) percentile plus Doppler abnormalities, or BW < 3(rd) percentile. Logistic regression-based predictive models were developed for predicting SGA and FGR. Models incorporated the a-priori risk from maternal characteristics, and mean arterial pressure, uterine artery Doppler, placental growth factor and soluble fms-like tyrosine kinase-1.
ResultsIn total, 9150 births were included. Of these, 979 (10.7%) qualified for a postnatal diagnosis of SGA and 462 (5.0%) for a prenatal diagnosis of FGR. For predicting SGA, the model achieved a detection rate of 35% for a false-positive rate (FPR) of 5% and 42% for a 10% FPR. The model's performance was significantly higher for predicting FGR (P < 0.001), with detection rates of 59% and 67%, for a FPR of 5% and 10%, respectively.
ConclusionThe predictive performance of first-trimester screening for cases with growth impairment by a combination of maternal characteristics and biophysical and biochemical markers is improved significantly when a prenatal and strict definition of FGR is used rather than a postnatal definition based on BW.

• 出版日期2017-3