MTHFR C677T Polymorphism and Pancreatic Cancer Risk: a Meta-analysis

作者：Liu, Xiang-Ming; Liu, Feng-Hua; Tang, Yong^*; Li, Qiang

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(8): 3763-3766.

DOI：10.7314/APJCP.2012.13.8.3763

• Methylenetetrahydrofolate reductase
• genetic polymorphism
• pancreatic cancer
• meta-analysis

Background: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial. Method: A literature search was performed using Pubmed and CNKI databases for published studies through May 2012. We performed a meta-analysis of all relevant case-control studies that examined the association between MTHFR C677T polymorphism and pancreatic cancer risk. Results: Finally, 9 individual case-control studies with a total of 1,299 pancreatic cancer cases and 2,473 controls were included into this meta-analysis. Results: This meta-analysis showed there was an obvious association between MTHFR C677T polymorphism and pancreatic cancer risk in East Asians (for allele model, OR = 1.67, 95% CI 1.11-2.51; For homozygote model, OR = 2.77, 95% CI 1.40-5.48; for recessive model, OR = 1.96, 95% CI 1.54-2.50; for dominant model, OR = 2.11, 95% CI 1.01-4.41). However, no significant association was found in Caucasians. Conclusion: The MTHFR C677T polymorphism is associated with pancreatic cancer risk, and a race-specific effect may exist in this association. More studies with a larger sample size are needed to further clarify this association.

• 出版日期2012
• 单位天津医科大学