Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP

作者：Kelsey Ilana; Nakayama Shizuka; Sintim Herman O^*

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(2): 881-885.

DOI：10.1016/j.bmcl.2011.12.039

• c-di-GMP
• Bacteria
• Biofilm
• Diamidinium intercalators
• G-quadruplex

C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via pi-stacking interactions.

• 出版日期2012-1-15