Stabilisation of an amorphous form of ROY through a predicted co-former interaction

作者:Corner Philip A; Harburn J Jonathan; Steed Jonathan W; McCabe James F; Berry David J*
来源:Chemical communications, 2016, 52(39): 6537-6540.
DOI:10.1039/c6cc02949c

摘要

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.

  • 出版日期2016