Aberrant ICOS+-T cell differentiation in women with spontaneous preterm labor

作者：Kaelble Florian; Mai Charlotte; Wagner Miriam; Schober Linda; Schaier Matthias; Zeier Martin; Spratte Julia; Fluhr Herbert; Steinborn Andrea^*

来源：American Journal of Reproductive Immunology, 2016, 76(5): 415-425.

DOI：10.1111/aji.12565

• cervical insufficiency
• immunosuppression
• pregnancy
• regulatory T cells
• preterm labor
• preterm premature rupture of fetal membranes

Problem: Recent studies revealed appropriate differentiation of recent thymic emigrant (RTE)regulatory T cells (Tregs) to be crucial for maintaining healthy pregnancy. Currently, the role of responder T cells (Tresps) is not known.
Method of study: Sixcolor flow cytometric analysis was used to detect differences in the differentiation of highly proliferative inducible costimulatory (ICOS)(+)RTETregs/Tresps and apoptosissensitive ICOSRTETregs/Tresps into mature naive (MN), CD31(+)memory and CD31memory Tregs/Tresps in women with spontaneous preterm labor (sPL) compared to healthy pregnancy.
Results: Healthy pregnancy was characterized by an increased differentiation of ICOS(+)and ICOSRTETregs, as well as ICOS(+)RTETresps via CD31(+)memory Tregs/Tresps into CD31memory Tregs/Tresps. Women with sPL showed an early interruption of RTETreg/Tresp differentiation. Instead, ICOS(+)MNTresps and partly ICOSMNTregs differentiated into CD31memory Tregs/Tresps, causing a significant reduction of both ICOS(+)Tregs and ICOS(+)Tresps, but an increase of ICOSTresps within total CD4(+)Thelper cells.
Conclusion: Aberrant differentiation of ICOS+T cells is associated with sPL.

• 出版日期2016-11