Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.

作者:Li Xiang; Vanner Stephanie; Wang Wenliang; Li Yongchang; Ariel Gallardo Victor; Magarvey Nathan A*
来源:Journal of Antibiotics, 2013, 66(7): 443-446.
DOI:10.1038/ja.2013.52

摘要

Macplocimine A (1), a rare naturally occurring 18-membered macrolide, was isolated from the marine-derived filamentous sulfur bacteria Thioploca sp. The structure was determined by a combination of spectroscopic techniques, including HRESIMS, 1D and 2D NMR analyses. 1 features a thymine group, which is attached to an aromatic fused 18-membered macrolide ring structure derived from a polyketide synthase biosynthetic pathway.

  • 出版日期2013-7