Actions of Probiotics on Trinitrobenzenesulfonic Acid-Induced Colitis in Rats

作者：Shiina Takahiko^*; Shima Takeshi; Naitou Kiyotada; Nakamori Hiroyuki; Sano Yuuki; Horii Kazuhiro; Shimakawa Masaki; Ohno Hiroshi; Shimizu Yasutake

来源：Biomed Research International, 2015, 2015: 528523.

DOI：10.1155/2015/528523

We investigated the actions of probiotics, Streptococcus faecalis 129 BIO 3B (SF3B), in a trinitrobenzenesulfonic acid- (TNBS-) induced colitis model in rats. After TNBS was administered into the colons of rats for induction of colitis, the rats were divided into two groups: one group was given a control diet and the other group was given a diet containing SF3B for 14 days. There were no apparent differences in body weight, diarrhea period, macroscopic colitis score, and colonic weight/length ratio between the control group and SF3B group, suggesting that induction of colitis was not prevented by SF3B. Next, we investigated whether SF3B-containing diet intake affects the restoration of enteric neurotransmissions being damaged during induction of colitis by TNBS using isolated colonic preparations. Recovery of the nitrergic component was greater in the SF3B group than in the control group. A compensatory appearance of nontachykininergic and noncholinergic excitatory components was less in the SF3B group than in the control group. In conclusion, the present study suggests that SF3B-containing diet intake can partially prevent disruptions of enteric neurotransmissions induced after onset of TNBS-induced colitis, suggesting that SF3B has therapeutic potential.

• 出版日期2015