Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients

作者：Zhang Guo Bin; Cui Xiang Li; Sui Da Li; Ren Xiao Hui; Zhang Zhe; Wang Zhong Cheng^*; Lin Song

来源：Journal of Neuro-Oncology, 2013, 113(2): 251-258.

DOI：10.1007/s11060-013-1102-x

• Glioblastoma multiforme
• Long-term survivor
• Short-term survivor
• MGMT promoter methylation
• 1p/19q LOH
• IDH1 mutation

This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival < 18 months) for detecting of MGMT promoter methylation, 1p/19q LOH and IDH1 mutation. IDH1 mutation and MGMT promoter methylation were significantly more frequent in the LTSs group (P = 0.039 and 0.017, respectively). The incidence of 1p/19q co-deletion was not significantly different (P = 1.0). IDH1 mutation and MGMT promoter methylation might be independent, significant, and favorable factors for LTSs with GBM.

• 出版日期2013-6
• 单位北京市神经外科研究所; 首都医科大学