Analysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone)

作者：Taschwer Magdalena; Weiss Jennifer A; Kunert Olaf; Schmid Martin G^*

来源：Forensic Science International, 2014, 244: E56-E59.

DOI：10.1016/j.forsciint.2014.09.007

• 4-Chloromethcathinone
• Clephedrone
• Cathinones
• Novel Psychoactive Substances (NPS)

Novel psychoactive drugs, such as amphetamine-, cathinone-, benzofury- and tryptamine derivatives, gained high popularity on the global drugmarket in the last years. These drugs are sold via the Internet as for example %26quot;research chemicals%26apos;%26apos;, %26quot;room odorizers%26apos;%26apos; or %26quot;lawn fertilizers%26apos;%26apos; by different online suppliers. They are also known as %26quot;Legal Highs%26quot;, among them, cathinone derivatives play an important role. Well known substituted cathinone derivatives are mephedrone, brephedrone and flephedrone. Since a couple of weeks, a chlorine substituted methcathinone derivative, namely clephedrone (4-chloromethcathinone), is commercially available via the Internet from www.deboralabs.com. %26lt;br%26gt;The goal of this study was to confirm identity of this substance, which was done successfully by GC-MS and NMR. Since all cathinone derivatives are chiral, it was found out, whether the purchased sample was present as a racemic mixture. For this purpose, methods for enantioseparation by GC and CE were developed and applied successfully. In case of CE a chiral selector was added, whereas chiral separation with GC-MS was done indirectly, after derivatization of clephedrone with trifluoroacetyl-L-prolyl chloride.

• 出版日期2014-11