Delivery of cisplatin from thermosensitive co-cross-linked chitosan hydrogels

作者：Moura M J^*; Gil M H; Figueiredo M M

来源：European Polymer Journal, 2013, 49(9): 2504-2510.

DOI：10.1016/j.eurpolymj.2013.02.032

• Thermosensitive hydrogel
• Chitosan
• Genipin
• Cisplatin
• Drug release

The aim of the present study was to investigate the in vitro cisplatin release from thermosensitive chitosan hydrogels, produced by ionic cross-linking and by ionic/covalent co-cross-linking. For that, two types of cisplatin-loaded hydrogels were prepared: chitosan hydrogels cross-linked with glycerol-phosphate disodium salt (as an ionic cross-linker) and chitosan hydrogels ionic/covalent co-cross-linked (using different amounts of genipin as covalent cross-linker). Both hydrogels were able to be produced in situ at physiologic conditions. %26lt;br%26gt;Regarding cisplatin release, all hydrogels exhibited a first initial rapid release reaching a maximum at about 3 h. However, the total amount of drug released was only 20% for the ionic hydrogel (without genipin) and about 60-70% for the ionic/covalent co-cross-linked hydrogels. This disparity was explained in terms of the type of cross-linking and hydrogels network structure. Changes in the initial drug loadings (0.6 and I mg/mL) as well as in the covalent cross-linker concentrations (0.10% and 0.20%, w/w) did not significantly affect the cisplatin release profiles.

• 出版日期2013-9