Absence of Galectin-1 accelerates CD8(+) T cell-mediated graft rejection

作者：Moreau Aurelie; Noble Alistair; Ratnasothy Kulachelvy; Chai Jian Guo; Deltour Louise; Cuturi Maria Cristina; Simpson Elizabeth; Lechler Robert; Lombardi Giovanna^*

来源：European Journal of Immunology, 2012, 42(11): 2881-2888.

DOI：10.1002/eji.201142325

• Cytokines
• Galectin-1
• Knockout mice
• Tc1 CD8+T cells
• Transplant immunology

Galectin-1 (Gal-1) is a member of a family of endogenous beta-galactose-binding proteins with a role in preventing autoimmune diseases and chronic inflammation. In this study, the involvement of Gal-1 in graft rejection was investigated by using Gal-1-deficient mice (Gal-1-/-). We demonstrate that in the absence of Gal-1, skin grafts are rejected earlier compared with those of WT mice, and that this is due to the role played by CD8+ T cells in graft rejection. The difference in graft survival observed between Gal-1-/- and WT mice was explained by both an increase in the percentage of antigen-specific CD8+ T cells and by preferential secretion of IFN-gamma and IL-17 by CD8+ T cells in Gal-1-/- mice compared with WT mice. This study suggests that endogenous expression of Gal-1 contributes to graft survival. The results obtained from the use of mice deficient in Gal-1 also confirm a key role for CD8+ T cells in graft rejection.

• 出版日期2012-11