New methods for the preparation of aryl 2-iminoimidazolidines

作者：O' Donovan Daniel H; Rozas Isabel^*

来源：Tetrahedron Letters, 2012, 53(34): 4532-4535.

DOI：10.1016/j.tetlet.2012.06.042

• 2-Iminoimidazolidines
• 1-Aryl-2-iminoimidazolidines
• 2-Aryl-2-iminoimidazolidines
• Cyclization

A divergent strategy for the synthesis of 1-aryl- and 2-aryl-2-iminoimidazolidines is presented. Cyclization of N-Boc-N%26apos;-aryl-N %26apos;%26apos;-(2-hydroxyethyl)guanidines in the presence of methanesulfonyl chloride and triethylamine or sodium hydride at 0 degrees C affords the corresponding 2-iminoimidazolidines in good yields.

• 出版日期2012-8-22