MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans

作者：Woeller Collynn F; Thatcher Thomas H; Van Twisk Daniel; Pollock Stephen J; Croasdell Amanda; Hopke Philip K; Xia Xiaoyan; Thakar Juilee; Sime Patricia J; Mallon Timothy M; Utell Mark J; Phipps Richard P^*

来源：Journal of Occupational and Environmental Medicine, 2016, 58(8): S89-S96.

DOI：10.1097/JOM.0000000000000769

Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

• 出版日期2016-8