New designs for clinical trials

作者：Melot Christian^*

来源：Critical Care Medicine, 2009, 37(1): S59-S64.

DOI：10.1097/CCM.0b013e318192111a

• randomized controlled trial
• Bayesian approach
• frequentist approach
• adaptive design
• sequential design
• clustered randomization
• crossover design
• factorial design
• parallel group design
• fixed-sample design

The pressures of ethics and equity on clinical trials have always been severe. The highest level of evidence about the usefulness of therapy is that obtained from well-planned, carefully conducted randomized, and where possible, double-blind clinical trials. Traditional frequentist statistics have been used predominantly, but a Bayesian approach may offer more flexibility by leveraging more information from the results of a clinical trial. Innovative designs can minimize the number of patients included in a trial and decrease the chance of maintaining a patent in an unfavorable treatment arm. (Grit Care Med 2009; 37[Suppl]:S59-S64)

• 出版日期2009-1