Addition of haptoglobin to RBCs storage, a new strategy to improve quality of stored RBCs and transfusion

作者：Wang Ying; Zhang Yuhua; Zhao Lian; Yin Yujing; Wang Quanli^*; Zhou Hong

来源：Medical Hypotheses, 2014, 82(2): 125-128.

DOI：10.1016/j.mehy.2013.09.020

Transfusion of red blood cells (RBCs) is an effective therapy in surgery and critical care. Comparing to fresh RBCs, the therapeutic effect of stored RBCs is greatly limited because of its loss of NO during storage, which leads to vasodilatation dysfunction upon transfusion. So far, there is no effective solution to this problem. Here, we summarize the protective effects of Haptoglobin (Hp) in RBCs storage and transfusion, by using data extracted from literature review. Because Free Hemoglobin (FHb) is the major factor responsible for rapid NO loss during storage, addition of FHb-sequestering protein Haptoglobin will prevent the loss of NO and improve the quality of stored RBCs.

• 出版日期2014-2
• 单位中国人民解放军军事医学科学院