Acyclovir-loaded sorbitan esters-based organogel: development and rheological characterization

作者：Rajpoot Kuldeep

来源：Artificial Cells, Nanomedicine and Biotechnology, 2017, 45(3): 551-559.

DOI：10.3109/21691401.2016.1161639

• virus
• isopropyl myristate
• nanoemulsion
• organogel
• rheology
• sorbitan monostearate
• topical

Herein, a nanoemulsion-based organogel (NEOG) system loaded with acyclovir has been developed for the effective treatment of herpes simplex virus infection via topical delivery. Pseudo-ternary phase diagram exhibited increase in non-birefrigent, optically isotropic region of organogel with Smix (K-w) ratio. The NEOG C showed good storage (G') and loss moduli (G ''), and more compact network structures. Gel-sol transition temperature (Tg) and fractal dimension (D-f) of NEOG system revealed increased density of the tubular network with K-w. Hence, high gelling ability of the developed NEOG system may attribute to the combination of sustained and site-specific delivery of drugs.

• 出版日期2017