Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis

作者：Duan Xiao Li; Gong Heng; Zeng Xian Tao^*; Ni Xiao Bing; Yan Yan; Chen Wen; Liu Guo Lei

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(7): 3299-3303.

DOI：10.7314/APJCP.2012.13.7.3299

• XPD
• excision repair
• polymorphism
• esophageal cancer
• susceptibility
• meta-analysis

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility[(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95% CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95% CI=1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95% CI=1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95% CI=1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95% CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.

• 出版日期2012
• 单位湖北大学