Antiproliferative and apoptosis induction of cucurbitacin-type triterpenes from Ibervillea sonorae

作者：Torres Moreno H; Velazquez C A; Garibay Escobar A; Curini Massimo; Marcotullio M C; Robles Zepeda R E

来源：Industrial Crops and Products, 2015, 77: 895-900.

DOI：10.1016/j.indcrop.2015.09.055

• Antiproliferative activity
• Apoptosis
• Ibervillea sonorae
• IC50

Two cucurbitacin-type triterpenes kinoin A (1) and kinoin B diglucoside (2) were isolated and characterized by chromatographic and spectroscopic techniques from the root of Ibervillea sonorae. By MTT assay their antiproliferative activity was evaluated and only compound 1 was able to inhibit the growth of HeLa, M12A(K) C3F6, A549 and RAW 264.7 cancer cell lines with a IC50 of 18.0, 31.4, 40.2, and 61.5 mu M, respectively. L-929 cell line used as a control was more resistant to compound 1 at IC50 values greater than 100 mu M. Apoptosis induction was quantified for a double staining by Annexin V/propidium iodide using flow cytometry, and it was observed that treatment of HeLa cells with compound 1 cause cell death by apoptosis.

• 出版日期2015-12-23