Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

作者:Cournia Zoe*; Allen Toby W; Andricioaei Ioan; Antonny Bruno; Baum Daniel; Brannigan Grace; Buchete Nicolae Viorel; Deckman Jason T; Delemotte Lucie; del Val Coral; Friedman Ran; Gkeka Paraskevi; Hege Hans Christian; Henin Jerome; Kasimova Marina A; Kolocouris Antonios; Klein Michael L; Khalid Syma; Lemieux M Joanne; Lindow Norbert; Roy Mahua; Selent Jana; Tarek Mounir; Tofoleanu Florentina; Vanni Stefano; Urban Sinisa; Wales David J; Smith Jeremy C
来源:Journal of Membrane Biology, 2015, 248(4): 611-640.
DOI:10.1007/s00232-015-9802-0

摘要

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

  • 出版日期2015-8
  • 单位rutgers