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摘要
A novel fluorescence sensor was designed and synthesized for detecting Cu2+ with high sensitivity and selectivity. The sensor showed a large red-shift in UV-vis spectra and obvious decline of fluorescent intensity in fluorescence emission spectra upon the addition of Cu2+. Bio-imaging studies and flow cytometric analysis revealed that this sensor was cell-permeable and could be used for detection of changes of intracellular Cu2+, suggesting the suitability of this sensor for biological application. Cell cytotoxicity studies demonstrated it was capable of chelating excess Cu2+ in vitro to modulate the biological functions of Cu2+ with low cytotoxicity. Therefore, this compound could be a promising fluorescent sensor combining the abilities of either detection or modulation of the biological function of Cu2+ in biological conditions.
- 出版日期2015
- 单位福州大学
