Use of oxytocin during early stages of labor and its effect on active management of third stage of labor

作者：Sosa Claudio G^*; Althabe Fernando; Belizan Jose M; Buekens Pierre

来源：American Journal of Obstetrics and Gynecology, 2011, 204(3): 238.e1.

DOI：10.1016/j.ajog.2010.10.005

• active management of labor
• augmentation
• induction
• oxytocin

OBJECTIVE: The purpose of this study was to evaluate whether the use of oxytocin during the first and second stages of labor is associated with a higher incidence of postpartum hemorrhage (PPH) in pregnant women who received active management of third stage of labor (AMTSL).
STUDY DESIGN: A secondary data analysis from vaginal deliveries in a hospital-based cohort study from 24 maternity hospitals in South America. The primary outcomes that were analyzed were moderate PPH (>= 500 mL of blood loss), severe PPH (>= 1000 mL of blood loss), and need of blood transfusion.
RESULTS: A total of 11,323 vaginal deliveries were included. The incidence of moderate and severe PPH was 10.8% and 1.86%, respectively. Overall, 36% of deliveries received AMTSL. There was no association between induced/augmented labor and moderate PPH (P = .753), severe PPH (P = .273), and blood transfusion (P = .603) in the population that received AMTSL.
CONCLUSION: AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor.

• 出版日期2011-3