Acephate exposure during a perinatal life program to type 2 diabetes

作者：Ribeiro Tatiane Aparecida^*; Prates Kelly Valerio; Pavanello Audrei; Malta Ananda; Tofolo Laize Peron; Martins Isabela Peixoto; de Oliveira Julio Cezar; Miranda Rosiane Aparecida; Gomes Rodrigo Mello; Vieira Elaine; da Silva Franco Claudineia Conationi; Barella Luiz Felipe; Francisco Flavio Andrade; Alves Vander Silva; Silveira Sandra da Silva; Moreira Veridiana Mota; Fabricio Gabriel Sergio; Palma Rigo Kesia; Sloboda Deborah M; de Freitas Mathias Paulo Cezar

来源：Toxicology, 2016, 372: 12-21.

DOI：10.1016/j.tox.2016.10.010

• Acephate
• Pregnancy
• Lactation
• Glucose metabolism
• Lipid metabolism
• Offspring

Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring healthcare costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.

• 出版日期2016-11-30