Anti-inflammatory effects of green soybean extract irradiated with visible light

作者：Tanaka Keiko; Ohgo Yasushi; Katayanagi Yuki; Yasui Kensuke; Hiramoto Shigeru; Ikemoto Hiroyuki; Nakata Yumi; Miyoshi Noriyuki; Isemura Mamoru; Ohashi Norio; Imai Shinjiro^*

来源：Scientific Reports, 2014, 4(1): 4732.

DOI：10.1038/srep04732

We conducted a preliminary investigation of the effects of visible light irradiation on plant extracts, and we observed a strong suppressive effect on interleukin (IL) 2 expression with the inhibition of c-Jun amino-terminal kinase (JNK) phosphorylation in Jurkat cells by visible light irradiation to ethanol extract from green soybeans (LIEGS). This effect was produced only by extracts from green soybeans (Glycine max) and not other-color soybeans. LIEGS suppressed the lipopolysaccharide-induced IL-6, IL-12 and TNF-alpha expression levels in human monocyte THP-1 cells in a concentration-dependent manner. LIEGS was applied for 8 weeks to NC/Nga mice. LIEGS suppressed the development of atopic dermatitis (AD)-like skin lesions and reduced the dermatitis scores of the mice. The light irradiation changed the various types of small-molecule compounds in extracts. Visible light irradiation to daidzein with chlorophyll b induced a novel oxidative product of daidzein. This product suppressed IL-2 expression in Jurkat cells.

• 出版日期2014-4-22