Monitoring the recrystallisation of amorphous xylitol using Raman spectroscopy and wide-angle X-ray scattering

作者：Palomaki Emmi; Ahvenainen Patrik; Ehlers Henrik; Svedstrom Kirsi; Huotari Simo; Yliruusi Jouko

来源：International Journal of Pharmaceutics, 2016, 508(1-2): 71-82.

DOI：10.1016/j.ijpharm.2016.04.074

• Amorphous
• Crystallization
• Raman spectrometry
• Wide-angle X-ray scattering
• Xylitol
• Non-ordered mesoporous silica

In this paper we present a fast model system for monitoring the recrystallization of quench-cooled amorphous xylitol using Raman spectroscopy and wide-angle X-ray scattering. The use of these two methods enables comparison between surface and bulk crystallization. Non-ordered mesoporous silica micro-particles were added to the system in order to alter the rate of crystallization of the amorphous xylitol. Raman measurements showed that adding silica to the system increased the rate of surface crystallization, while X-ray measurements showed that the rate of bulk crystallization decreased. Using this model system it is possible to measure fast changes, which occur in minutes or within a few hours. Raman-spectroscopy and wide-angle X-ray scattering were found to be complementary techniques when assessing surface and bulk crystallization of amorphous xylitol.

• 出版日期2016-7-11