Development and Characterization of Biocompatible Fullerene [C-60]/Amphiphilic Block Copolymer Nanocomposite

作者：Chaurasia Alok^*; Sahoo Nanda Gopal; McLeskey James T Jr; Hu Xiao

来源：Journal of Spectroscopy, 2015, 2015: 578160.

DOI：10.1155/2015/578160

We report a supramolecular process for the synthesis of well-defined fullerene (C-60)/polymer colloid nanocomposites in an aqueous solution via complex formation. A biocompatible triblock poly(4-vinylpyridine)-b-polyethylene-b-poly(4-vinylpyridine), P4VP(8)-b-PEO105-b-P4VP(8), was synthesized by atom transfer radical polymerization. The block copolymer formed complexes with C-60 in toluene and resulted in fullerene assembly in cluster form. Nanocomposite dispersion in an aqueous solution could be obtained using an aged solution of the polymer/C-60/toluene solution by a solvent evaporation technique. The UV-Vis and FTIR spectroscopy confirmed the complex formation of fullerene with the polymer which plays a significant role in controlling the PDI and size of polymer/C-60 micelles in the toluene solution. The particle size and morphology of P4VP(8)-b-PEO105-b-P4VP(8) and P4VP(8)-bPEO(105)-b-P4VP(8)/C-60 mixture were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). In a cytotoxicity test, both pure polymer and the resulting polymer/C-60 composite in water showed more than 90% cell viability at 1 mg/mL concentration.

• 出版日期2015
• 单位南阳理工学院