Multifunctional Hollow Mesoporous Silica Nanocages for Cancer Cell Detection and the Combined Chemotherapy and Photodynamic Therapy

作者：Wang, Tingting; Zhang, Lingyu; Su, Zhongmin^*; Wang, Chungang; Liao, Yi; Fu, Qin

来源：ACS Applied Materials & Interfaces, 2011, 3(7): 2479-2486.

DOI：10.1021/am200364e

• mesoporous silica nanocage
• drug delivery
• photodynamic therapy
• sustained release
• cancer therapy
• fluorescence imaging

Highly uniform and multifunctional hollow mesoporous silica nanocages that combined excellent properties (good biocompatibility, fluorescence imaging, drug delivery, and dual-mode cancer therapy) in one single system were synthesized. Dye molecules labeled in the nanocages could be used as traceable detectors in fluorescence imaging. A chemotherapeutic drug, doxorubicin (DOX), has been loaded into the nanocages with a high storage capacity due to the large cubic cavities and could be released through the penetrating mesoporous channels in a sustained fashion. Hematoporphyrin molecules were also covalently doped in the nanocages and allowed for photodynamic therapy. More importantly, a cooperative, synergistic therapy combining chemotherapy and photodynamic therapy exhibited high therapeutic efficacy for cancer therapy in vitro.

• 出版日期2011-7
• 单位东北师范大学; 首都师范大学