Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

作者：Arnold Forest W; Lopardo Gustavo; Wiemken Timothy L; Kelley Robert; Peyrani Paula; Mattingly William A; Feldman Charles; Gnoni Martin; Maurici Rosemeri; Ramirez Julio A; Arnold Forest^*; Peyrani Paula; Ramirez Julio; Ayesu Kwabena; File Thomas Jr; Burdette Steven; Blatt Stephen; Restrepo Marcos; Bordon Jose; Gross Peter; Musher Daniel; Marrie Thomas; Weiss Karl; Roig Jorge; Lode Harmut; Welte Tobias; Aliberti Stephano; Blasi Francesco; Cosentini Roberto

来源：Respiratory Medicine, 2018, 140: 115-121.

DOI：10.1016/j.rmed.2018.05.020

• Community-acquired pneumonia
• Mortality
• Bacteremia
• Antimicrobial treatment

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide.
Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included inhospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability.
Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50-1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30-0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different.
Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia.

• 出版日期2018-7