Assessing the predictive value of hyaluronan binding ability for the freezability potential of human sperm

作者：Yogev Leah^*; Kleiman Sandra E; Hauser Ron; Botchan Amnon; Lehavi Ofer; Paz Gedalia; Yavetz Haim

来源：Fertility and Sterility, 2010, 93(1): 154-158.

DOI：10.1016/j.fertnstert.2008.09.067

• Freezability
• sperm bank donor
• sperm hyaluronan-binding assay

Objective: To evaluate the predictive value of a sperm maturation test using the hyaluronan-binding assay (HBA) for freezability potential; and to determine the effect of freezing-thawing on HBA results.
Design: Prospective study.
Setting: Andrology laboratory at a teaching hospital.
Patient(s): Candidates for sperm bank donation (n = 113) and active sperm bank donors (n = 16).
Intervention(s): Semen analyses including HBA and sperm freezing-thawing.
Main Outcome Measure(s): Percentage of sperm HBA results and other sperm parameters in relation to freezing thawing results.
Result(s): The predictive value of HBA for high freezability value (>= 40% postthaw motility) was significant. However, 1- and 4-hour percentage of motility had a higher predictive value for good freezability. A better prognostic value than that of HBA results was also found for sperm concentration and percentage of normal morphology. Freezing-thawing had no significant influence on HBA results.
Conclusion(s): To the best of our knowledge this is the first demonstration that sperm maturation, determined by the HBA test, has a low value for predicting freezing-thawing sperm survival. (Fertil Steril(R) 2010;93:154-8.

• 出版日期2010-1-1