A randomized controlled trial of intranasal ketamine in migraine with prolonged aura

作者：Afridi Shazia K; Giffin Nicola J; Kaube Holger; Goad**y Peter J^*

来源：Neurology, 2013, 80(7): 642-647.

DOI：10.1212/WNL.0b013e3182824e66

Objective: The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura.
Methods: We performed a double-blinded, randomized parallel-group controlled study investigating the effect of 25 mg intranasal ketamine on migraine with prolonged aura in 30 migraineurs using 2 mg intranasal midazolam as an active control. Each subject recorded data from 3 episodes of migraine.
Results: Eighteen subjects completed the study. Ketamine reduced the severity (p = 0.032) but not duration of aura in this group, whereas midazolam had no effect.
Conclusions: These data provide translational evidence for the potential importance of glutamatergic mechanisms in migraine aura and offer a pharmacologic parallel between animal experimental work on cortical spreading depression and the clinical problem.

• 出版日期2013-2