NHC-Catalyzed Spiro Bis-Indane Formation via Domino Stetter-Aldol-Michael and Stetter-Aldol-Aldol Reactions

作者:Sanchez Larios Eduardo; Holmes Janice M; Daschner Crystal L; Gravel Michel*
来源:Organic Letters, 2010, 12(24): 5772-5775.
DOI:10.1021/ol102685u

摘要

Two novel domino NHC-catalyzed spirocyclizations are described herein, enabling the rapid construction of three new carbon-carbon bonds and a quaternary center with high diastereoselectivity. A variety of Spiro bis-indane structures are assembled in a single step from simple o-phthaldialdehyde derivatives.

  • 出版日期2010-12-17