Are Ratings on the Positive and Negative Syndrome Scale for Schizophrenia Biased by Personality Traits?

作者：Huber C G^*; Hoppe A; Agorastos A; Andresen B; Naber D; Schroeder K

来源：Pharmacopsychiatry, 2012, 45(4): 156-161.

DOI：10.1055/s-0031-1298022

• five factor model
• PANSS
• personality traits
• psychopathology
• schizophrenia spectrum disorder
• SCID-II

Objective: The aim of this study was to estimate the potential bias by personality traits for ratings on the Positive and Negative Syndrome Scale (PANSS).
Method: Personality dimensions (five factor model), personality traits (SCID-II) and PANSS scores were assessed prospectively in 45 patients with schizophrenia spectrum disorders (SSD).
Results: Borderline (r = 0.34; p = 0.021), avoidant (r = 0.66; p < 0.001) and depressive (r = 0.51; p < 0.001) personality traits were significantly correlated with the PANSS total score. There were significant correlations for all PANSS subscores with the exemption of PANSS positive. In multi-variate analyses, the final models for PANSS total score and PANSS depressive explained a total of 45.3% and 54.3% of the variance. Avoidant traits could lead to a difference of 13.1 (95% Cl: 5.6-20.7) points regarding PANSS total score, depressive traits could cause differences of 4.8 points (95% CI: 2.2-7.3) for PANSS depressive subscore.
Conclusion: Although PANSS positive subscore and PANSS excited component are relatively robust against bias by personality traits, PANSS total score and the remaining subscores are affected to a clinically relevant degree. Outcome studies in SSD patients should control for personality traits.

• 出版日期2012-6