Stellatolide H, a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp.

作者：Nakamukai Shohei; Takada Kentaro^*; Furihata Kazuo; Ise Yuji; Okada Shigeru; Morii Yasuhiro; Yamawaki Nobuhiro; Takatani Tomohiro; Arakawa Osamu; Gustafson Kirk R; Matsunaga Shigeki^*

来源：Tetrahedron Letters, 2018, 59(26): 2532-2536.

DOI：10.1016/j.tetlet.2018.05.033

• Marine natural products
• Marine sponge
• Peptide lactone
• Structure elucidation
• Cytotoxic

Stellatolide H (1) was isolated from a deep-sea sponge Discodermia sp. as the cytotoxic constituent. The planar structure of 1 was elucidated on the basis of the NMR spectroscopic and mass spectrometric data. The absolute configurations of the constituent amino acid residues were determined by the Marfey's method. Stellatolide H (1) is a peptide lactone of the callipeltin class with its N-terminus blocked by 3-hydroxy-6,8-dimethyldeca-(4Z,6E)-dienoic acid (Hdda).

• 出版日期2018-6-27