A new Ce(III) compound based on 5-aminotetrazole-1-propanoic acid for ablation of HeLa cells

作者：Gu, Xiao Qing; Zhu, Ting; Zhao, Liang; Zhang, Xin; Yang, Gao Wen^*; Li, Qiao Yun^*

来源：Journal of Coordination Chemistry, 2018, 71(22): 3639-3647.

DOI：10.1080/00958972.2018.1524887

• Ce(III)
• Hatzpa
• HeLa cell
• in vitro

Developing new drugs for the treatment of cancer is of great significance. Coordination compounds based on tetrazole-carboxylates are the potential candidates for cancer treatment. In this article, [Ce-2(atzpa)(4)(H2O)(8)](NO3)(2)center dot 2H(2)O based on 5-aminotetrazole-1-propanoic acid (Hatzpa) and Ce(NO3)(3)center dot 6H(2)O has been designed and prepared. Single-crystal X-ray diffraction reveals that the compound is binuclear in which atzpa acts as a bridging ligand. In order to improve the water dispersity of this compound, PEG(-5000) (poly(ethyleneglycol(-5000))) was coated on [Ce-2(atzpa)(4)(H2O)(8)](NO3)(2)center dot 2H(2)O to prepare the nanoparticles (NPs) in distilled water. In vitro study on HeLa cells shows that Hatzpa is nontoxic itself, while [Ce-2(atzpa)(4)(H2O)(8)](NO3)(2)center dot 2H(2)O NPs show high toxicity. Such NPs have a low half-inhibitory concentration (IC50) of 24 mu g mL(-1) (2.0 x 10(-)5 M). In addition, such NPs are able to inhibit the migration of HeLa cells even at a low concentration effectively, showing their potential to inhibit the transfer of tumors in vivo. @@@ [GRAPHICS] @@@ .

• 出版日期2018-11-17
• 单位常熟理工学院