A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union

作者：Grover Rajesh K; Zhu Xueyong; Nieusma Travis; Jones Teresa; Boero Isabel; MacLeod Amanda S; Mark Adam; Niessen Sherry; Kim Helen J; Kong Leopold; Assad Garcia Nacyra; Kwon Keehwan; Chesi Marta; Smider Vaughn V; Salomon Daniel R; Jelinek Diane F; Kyle Robert A; Pyles Richard B; Glass John I; Ward Andrew B; Wilson Ian A; Lerner Richard A^*

来源：Science, 2014, 343(6171): 656-661.

DOI：10.1126/science.1246135

We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody binding. Protein M binds with high affinity to all types of human and nonhuman immunoglobulin G, predominantly through attachment to the conserved portions of the variable region of the kappa and lambda light chains. Protein M blocks antibody-antigen union, likely because of its large C-terminal domain extending over the antibody-combining site, blocking entry to large antigens. Similar to the other immunoglobulin-binding proteins such as Protein A, Protein M as well as its orthologs in other Mycoplasma species could become invaluable reagents in the antibody field.

• 出版日期2014-2-7